Articles
Research context and product platform updates from Padakonn Pharma.
Chronic kidney disease links renal dysfunction with vascular and cardiac fibrosis. This review examines MBG–Na⁺/K⁺-ATPase signaling, human biomarker evidence, and targeted...
Marinobufagenin (MBG) drives renal and vascular fibrosis via Na+/K+-ATPase and Fli1. Review mechanisms, anti-MBG antibodies, and extracorporeal immunoadsorption.
Every year millions die prematurely of complications related to chronic kidney disease (CKD). Main causes of death are connected with cardiovascular (CV) complications. This mini...
Marinobufagenin (MBG) is implicated in chronic kidney disease, where it removes Fli1-induced inhibition of the collagen-1. We hypothesized that in nephrectomized rats, aortic...
Marinobufagenin, NKA (Na/K-ATPase) inhibitor, causes vasoconstriction and induces fibrosis via inhibition of Fli1 (Friend leukemia integration-1), a negative regulator of collagen...
Previously we demonstrated that in patients with preeclampsia elevated levels of endogenous Na/K-ATPase inhibitor, marinobufagenin, cause inhibition of Fli1, a negative regulator...
Editorial comment on Qian et al.: spot urine sampling for sodium estimation, salt intake, hypertension, and the link to vascular fibrosis via cardiotonic steroids and Fli1.
Despite prophylaxis and attempts to select a therapy, the frequency of preeclampsia does not decrease and it still takes the leading position in the structure of maternal...
Background: Previous studies implicated cardiotonic steroids, including Na/K-ATPase inhibitor marinobufagenin (MBG), in the pathogenesis of preeclampsia (PE).
We have shown that the cardiotonic steroid marinobufagenin (MBG) is elevated in clinical and experimental renal disease, and significantly contributes to the development of...
Marinobufagenin (MBG) promotes natriuresis via inhibition of renotubular Na/K-ATPase (NKA) and causes vasoconstriction via inhibition of vascular NKA.
Cardiotonic steroids (CTS) are implicated in pathophysiology of uremic cardiomyopathy. In the present study, we tested whether a monoclonal antibody (mAb) against the...
In patients with chronic kidney disease and partially nephrectomized rats, plasma marinobufagenin but not endogenous ouabain was elevated and erythrocyte Na/K-ATPase was inhibited.
Endogenous cardiotonic steroids have been postulated to play important roles in health and disease for nearly half a century. This review focuses on physiology, pharmacology, and...